2021 NFL picks, score predictions for Week 2

Los Angeles Rams (1-0) at Indianapolis Colts (0-1)

Sunday, September 19, 1PM ET

If the Indianapolis Colts thought they had a tough time against the Seattle Seahawks defense, they’ve got another eye-opener coming when the Los Angeles Rams come to town. This is one of the top defenses in the league, and they’re not going to take this matchup lightly.

In fact, expect Carson Wentz to be on the run all game long. The Rams are one of the top teams in the NFL when it comes to putting pressure on opposing passers, with guys like Aaron Donald and Leonard Floyd up front. Wentz should find himself on the ground early and often in this one, with a few turnovers occurring as a result.

And if the Indy defense couldn’t contain Russell Wilson, I don’t imagine they’ll have much better success against Matthew Stafford and Co. While not as dynamic of a group as Seattle’s offense, the Rams are still more than capable of running up the score.

I’m going to put it bluntly — the Colts are in for a rough game in Week 2. The Rams are going to come to town, knock their opponents around for 60 minutes, and walk away with the W.

Prediction: Rams win 40-17