2021 NFL picks, score predictions for Week 6

Oct 3, 2021; Inglewood, California, USA; Arizona Cardinals quarterback Kyler Murray (1) moves out to pass against the Los Angeles Rams during the first half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports
Oct 3, 2021; Inglewood, California, USA; Arizona Cardinals quarterback Kyler Murray (1) moves out to pass against the Los Angeles Rams during the first half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports /
facebooktwitterreddit
Prev
10 of 14
Next
Photo by Christian Petersen/Getty Images
Photo by Christian Petersen/Getty Images /

Arizona Cardinals (5-0) at Cleveland Browns (3-2)

Sunday, October 17, 4:05PM ET

I’m sorry, but there’s no way the Cleveland Browns are going to contain the Arizona Cardinals. They couldn’t keep the Chargers from putting up 49 points, and might give up even more to one of the most dangerous and explosive offenses we’ve seen in years.

I know the Cardinals were relatively quiet in Week 5, but that was against a quality San Francisco defense. As we also saw in Week 5, the Browns don’t possess anything resembling that. In fact, it’s one of their biggest weaknesses and one of the reasons people aren’t quite buying Cleveland as legitimate contenders.

Look for Kyler Murray to have another career day for the Cardinals offense, finding his many weapons early and often on the way to copious yards and points. If you’ve got any of Arizona’s top offensive players on your fantasy team, you’d be wise to start them in Week 6.

The Browns will keep it from becoming a blowout with the help of their own talented offense, but they don’t have the talent to slow Murray. The Cardinals light up the scoreboard and continue their winning ways, remaining the only undefeated team in the league.

Prediction: Cardinals win 41-27 | Spread: Browns (-3)