The NFL season is flying by, and it honestly needs to slow down. We're already looking at Week 10 action here in the 2025 season, which is wild to think about. Across both conferences, the playoff picture is beginning to take shape.
And at the moment, there would be some surprise division finishes. Both conferences also feel wide open right now, and it's really been a season where parity has dominated. There are bound to be some upsets and other shocking finishes here in Week 10.
It's a weekly thing at this point. As we have done all season, we've got our picks and score predictions for every single Week 10 game, so let's get into it here.
Cincinnati, Dallas, Tennessee, and Kansas City are on their bye in Week 10
NFL picks and score predictions for every Week 10 game in the 2025 season
Las Vegas Raiders @ Denver Broncos
Thurday, November 6th, 8:15 PM ET
The Denver Broncos are riding a six-game win streak and host the Las Vegas Raiders on Thursday Night Football. The Broncos have become experts at fourth quarter comebacks and are seeing QB Bo Nix kick it into another gear when needed late in the game.
The Raiders have a near-reversed record as Denver. Vegas lost in Week 9 to the Jacksonville Jaguars and now drop to 2-6 on the season. This team really can’t do much of anything well, and their decisions to hire Pete Carroll and add Geno Smith as the starting QB have turned out to be horrific ones.
Vegas could keep this game close early on, but the Broncos did sweep the Raiders last year, and the Raiders are honestly a bit worse. With Denver having not lost at home in a calendar year, Mile High is becoming a place where it’s nearly impossible to beat the home team.
Denver is going to pull away in the end and improve to 8-2 on the season, sending the Raiders further down the drain.
Prediction: Broncos win 27-17
Atlanta Falcons @ Indianapolis Colts
Sunday, November 9th, 9:30 AM ET (Germany)
The Atlanta Falcons are bottoming out before our eyes. Now losers of three games in a row, Atlanta needs to figure something out, or major change could be on the horizon. This team has way too much talent to be 3-5 through eight games.
On the flip side, the 7-2 Indianapolis Colts lost at Pittsburgh in Week 9 and honestly looked quite bad. QB Daniel Jones showed signs of his old self, and that’s never a good thing. Indy is technically the home team in this one even though the game is in Germany.
It’s obviously a neutral site, and that should benefit the Falcons. The one thing I am keeping an eye out for is how Jones looks in this one, as he’s been great all year, but the Colts’ schedule is only going to get tougher, and the Falcons do have a stingy defense.
As for Atlanta, I would expect that they could put a few touchdowns on the board, as they have elite weapons and really don’t have a ton of trouble scoring points, for the most part. With everything laid out, this feels like a close game coming down to who can make the fewest mistakes.
And in certain games in today’s NFL, that’s simply how things shake out sometimes. The Colts are obviously the better team here and only have two losses on the season for a reason - the Falcons are going to hang around, but the Colts hang on for the win, sending Atlanta packing with their fourth loss in a row.
The Colts would also maintain their lead in the AFC South with a win and continue to give themselves a great shot at the first overall seed in the AFC.
Prediction: Colts win 24-20
New York Giants @ Chicago Bears
Sunday, November 9th, 1:00 PM ET
The New York Giants are spiraling and are now 2-7 on the season, losers of four out of the last five games. At one point in time, the Giants had improved to 2-4 on the season with a win over the Eagles a few weeks ago, and they were then on the doorstep of a 3-4 start heading into the fourth quarter of their game against the Denver Broncos.
Ever since Bo Nix took that game over, the Giants have not been able to rebound since. On the flip side, the Chicago Bears are 5-3 after one of the wildest finishes you will ever see in the NFL. The Bears and Bengals combined for nearly 90 points in a game where each team traded late-game blows.
The Bears won the game on a long Colston Loveland touchdown reception, and that was mainly due to the Bengals not knowing how to tackle anyone. Anyway, the Bears return home and have a strong 6-3 start staring them in the face, but the main thing that could mess things up is the Giants’ defensive line, which could create a ton of pressure.
The Bears’ defense is also shaky at best, so I do not really see an avenue where Chicago pulls away. With how well Jaxson Dart has played this year given the circumstances, he’ll have his chances against Chicago.
But Caleb Williams is more of a proven commodity in the NFL right now, and the Bears are simply a better team, which should not be up for debate. Chicago is going to win this game by one point and keep their NFC North hopes alive.
After the crazy weekend in the NFC North, every team either has four or five wins. Anyway, the Bears win 24-23 and are able to perform and come out victorious in another late-game situation.
Prediction: Bears win 24-23
Buffalo Bills @ Miami Dolphins
Sunday, November 9th, 1:00 PM ET
This could get very ugly for the Miami Dolphins, and you almost have to feel bad for them at this point. Miami is now 2-7 on the season after a loss to the Baltimore Ravens this past week, and they traded Jaelan Phillips to the Philadelphia Eagles on Monday.
The Dolphins are expected to trade some more players before the deadline on Tuesday, as they parted ways with GM Chris Grier after a failed tenure that amounted to zero playoff wins. Miami needs a reset in the worst way and probably needs a new QB.
Them continuing to lose is not going to be good in the present, but it could benefit them in the long-term, as they’ll end up with higher draft picks. On the other sideline is the Buffalo Bills, now winners of two games in a row and having just taken down the Kansas City Chiefs in Week 9.
It was a very strong win for Buffalo, as the defense played great and held Patrick Mahomes to one of the worst starts of his NFL career. The Bills don’t feel quite as good this year as they were in 2024, but they’re 6-2 for a reason and can surely see the uphill battle they have to climb in the AFC East.
The Patriots are still in first place, as they are now 7-2 on the season. Buffalo knows how to stack wins in the regular season and have owned the Miami Dolphins recently. This game is going to get out of hand quite quickly, as most of the Dolphins’ players can clearly see that this team is not going to be very competitive going forward.
Buffalo could win this game by multiple touchdowns and earn their seventh win of the 2025 NFL Season.
Prediction: Bills win 38-13
Baltimore Ravens @ Minnesota Vikings
Sunday, November 9th, 1:00 PM ET
The Baltimore Ravens have Lamar Jackson back in the mix and are now winners of two games in a row after a shaky 1-5 start, but it’s been injuries that have derailed things for the Ravens this year. It’s not about a lack of talent - they just cannot stay healthy.
Well, the biggest absence was the two-time MVP and future Hall of Fame QB, which is understandable. The Ravens recently blew out the Miami Dolphins and are now in Minnesota to face the Vikings, a team that went into Detroit and beat the Lions.
Both teams are coming up on a huge part of their season, as the NFC North is actually still well within reach for the Vikings, and the same can be said with the AFC North and the Ravens. However, in this game, the Ravens have the advantage.
Lamar Jackson is going to be the best player on the field, and with the Ravens, overall, getting healthier, they honestly feel like a 5-3 team and not a 3-5 team. The Vikings still have to deal with some degree of uncertainty with JJ McCarthy, as he’s only made a handful of starts in the NFL.
Minnesota is a tough place to play, but the Ravens are going to see their QB make one more play and do just enough to guide them to a win, improving Baltimore to 4-5 and seeing Minnesota drop to 4-5 in the process.
If the Ravens are able to get to 4-5 after this huge win, it might then be time to talk about this team potentially going on a run and making the playoffs. Ravens win in a tight, one-point game.
Can the Ravens keep this going?
Prediction: Ravens win 23-22
Cleveland Browns @ New York Jets
Sunday, November 9th, 1:00 PM ET
This could end up being one of the ugliest games of the 2025 NFL Season. The Cleveland Browns and New York Jets are two of the worst teams in the NFL, and that isn’t up for discussion. Both teams are also in a similar-ish situation.
The Browns have seen the Deshaun Watson trade blow up in their faces, and it’s having impacts years down the line. Cleveland is fielding a playoff-caliber defense, but they just cannot get the offense right.
And until they do that, which entails getting a franchise QB, they’ll continue to circle the drain. On the flip side, the New York Jets are led by a new regime and are obviously on the struggle bus, and it kind of does center around the QB, but the defense is bad, and the overall roster just isn’t good.
Believe it or not, the Browns are the better team in this one and should win this game. Justin Fields has been dreadful this year, and the Jets’ defense hasn’t been good, either. The Browns’ defense is the best unit in this one, and head coach Kevin Stefanski has won some games in the NFL.
I would expect the Browns to win this one, but at this point, wins do not help either franchise - both teams need a hard reset on offense and have to at least rebuild that side of the ball through the NFL Draft before they get back to competing.
Cleveland wins an ugly dogfight by four points, sending the Jets down the drain even more.
I will be interested to see how the Browns and Jets operate at the deadline, as both teams actually have an argument to 'buy low' on some cheap, young talent.
Prediction: Browns win 17-13
New England Patriots @ Tampa Bay Buccaneers
Sunday, November 9th, 1:00 PM ET
I say this very carefully - could this be a sneak peek of the Super Bowl this year…?
Two of the more fun teams of the season square off in Tampa Bay this week, as the red-hot Patriots are in Tampa to face the Buccaneers. The Pats are now winners of six in a row and are 7-2 on the season, and the Buccaneers are a strong 6-2 and distancing themselves in the NFC South yet again.
What we have on display in this matchup in Week 10 are two of the best, most efficient QBs in the NFL this year. Both Baker Mayfield and Drake Maye are playing their tails off, but the Pats are actually the more complete team here. They’re balanced on both sides of the ball.
I will say that the Patriots are overperforming a bit, as the roster talent is good, but it’s not there yet. Tampa does have the better roster here and might have an advantage here since this game is at home.
New England looks to keep their six-game winning streak alive, and a win over an NFC juggernaut would do a lot in our belief in this team. Many have criticized the Patriots for only beating up on bad teams this year, but they cannot control who they play.
I would expect the Patriots keep this game close, as head coach Mike Vrabel is a master at getting the most out of his players, but I just think the Buccaneers are going to play a complete game and will notch a late score to take a lead and not let it go.
The Buccaneers win this one by two points in yet another dramatic finish here in the 2025 NFL Season. The Patriots drop to 7-3 and could see their AFC East lead slowly disappear. Moreover, if the Colts and Broncos each win in Week 10 and the Pats lose, New England is going to drop in the overall AFC standings as well.
Prediction: Buccaneers win 30-28
New Orleans Saints @ Carolina Panthers
Sunday, November 9th, 1:00 PM ET
How about those Carolina Panthers? The Panthers are now 5-4 on the season after a marvelous but ugly win over the Green Bay Packers in Week 9 of the 2025 NFL Season. The New Orleans Saints are on the total other end of the spectrum and are in a massive rebuilding process with a first-year head coach and now a rookie QB under center.
New Orleans is barelling toward the first overall pick in the 2026 NFL Draft, and that could benefit them in the long-term, as this team needs a franchise QB and also needs a series of young players on their rookie deals.
The Panthers are all of a sudden well within the NFC playoff picture and honestly might not be out of the NFC South race entirely.
Carolina gets this game at home and have a great shot at a shocking 6-4 start, which would only increase their playoff chances. What we have seen from Carolina this season is a much-improved defense and a huge emphasis on the running game thanks to Rico Dowdle, who the team signed in free agency.
The Panthers should be able to control the clock and run wild with Dowdle - Carolina’s defense isn’t great, so rookie QB Tyler Shough should be able to move the ball a bit.
All in all, though, the Panthers are the better team and should be able to play well enough to win this game. The Saints continue to stack losses in a lost season, and Carolina keeps their shocking season alive.
If the Panthers win and improve to 6-4, should we begin to take them seriously as a potential playoff team? I think we need to see more from Bryce Young in that event.
Prediction: Panthers win 23-14
Jacksonville Jaguars @ Houston Texans
Sunday, November 9th, 1:00 PM ET
This could end up being a huge game that sways the AFC South one way or the other. In Week 9, the Jacksonville Jaguars went back and forth with the Las Vegas Raiders, and they were able to come out victorious.
Jacksonville is now 5-3 on the season and still in the AFC playoff picture. First-year head coach Liam Coen has done an awesome job with this franchise, but the one thing that I keep going back to is the overall ‘meh’ play of Trevor Lawrence.
At some point, we have to see more from Lawrence, but I am approaching an opinion where I don’t think we ever will. Lawrence has been just OK in his NFL career thus far and really isn’t anything more than an average QB at this point.
The Houston Texans likely come into this game without CJ Stroud, as I am not sure he’d be able to clear the NFL’s concussion protocol in time, but that’s not any sort of guarantee one way or the other. Stroud left the Texans’ loss early due to a hard hit from Denver Broncos’ CB Kris Abrams-Draine.
The hit was clean, but Stroud slid right as Abrams-Draine went for the take down. If CJ Stroud is not playing in this game, I think the Jaguars win, and I personally do not believe he will. Yes, the Texans’ defense has been insane this year, but Jacksonville is 5-3 for a reason.
The Jags’ defense is also quite good and should be able to capitalize on a couple of turnovers no matter who is under center. This could be another ugly game Houston finds itself in, and if Stroud is out, they’ll have to lean on that defense a lot more than usual.
Heck, Houston might need a defensive touchdown in order to win this game, but I just can’t really see a path for a Texans’ win without CJ Stroud, so for right now, we will predicft a close Jaguars’ victory as they improve to 6-3 on the season.
Houston would drop to 3-6 and see their season slip away even more. It’s been one of those years for Houston, unfortunately.
Prediction: Jaguars win 20-17
Arizona Cardinals @ Seattle Seahawks
Sunday, November 9th, 4:05 PM ET
The Arizona Cardinals will have played on Monday Night Football this week against the Dallas Cowboys, and the expectation here, at least in my eyes, is that they lose that game and continue down this unfortunate season.
The Cardinals did start out with a solid 2-0 record, but they have not won a game since, and the QB position has gotten very interesting, as it seems like we might actually have a bit of a soft benching of Kyler Murray, who has been their QB since 2019 but is someone who really hasn’t emerged as anything special for the position.
It’s clear that Murray is just not a special QB and not someone who a team can consistently with win. Furthermore, the regime that brought in Murray is long gone, so you just never know what this front office is going to do.
On the flip side, the Seattle Seahawks return home after a massive blowout win over the Washington Commanders on Sunday Night Football. Seattle is one of the more balanced teams in the NFL and can hurt opponents on offense or on defense.
You would like to see their rushing attack take a step forward, but that might actually come with a trade deadline move at guard instead of adding a running back.
The Seahawks are going to win this game and improve to 7-2 on the season no matter what the Cardinals end up doing on MNF against the Cowboys. Seattle is truly a special team and could make a deep playoff run.
Them being in a division with the Los Angeles Rams does complicate things, as the NFC West might honestly come down to Week 18 results. For this game, though, the Seahawks win by multiple scores and keep their outstanding season going.
The Cardinals lose and are again left with way more questions than answers.
Prediction: Seahawks win 30-20
Los Angeles Rams @ San Francisco 49ers
Sunday, November 9th, 4:25 PM ET
Hats off to the San Francisco 49ers for their perseverance this year - this team is not 6-3 on the season after beating the New York Giants in Week 9. The 49ers have dealt with a ton of injuries this year and have been without Fred Warner, Nick Bosa, and Brock Purdy for a while now.
Mac Jones has been the starting QB for most of the season and has honestly played quite well. I do believe there is an entirely different discussion about the QB position for the rest of 2025 and beyond if Jones keeps playing well.
And you can’t really argue with a 6-3 record, as the Niners have matched their win total from 2024 already. They should be able to make the playoffs this year, but I do not get the feeling that they are going to hold up at the end in the NFC West race.
The LA Rams, on the other hand, are 6-2 on the season after a blowout win over the New Orleans Saints, and while the 49ers actually won this matchup earlier in the season, the Rams are going to win this one.
Matthew Stafford is playing a different game than anyone else out there, and he should be seen as an MVP candidate. The Rams are much healthier than the 49ers, and Sean McVay can see how important this game is.
But it’s a divisional game, and those are typically very close, so I would not expect a blowout either way, but the Rams are going to win this one by a pretty typical 27-21 score, improving to 7-2 and sending the 49ers to 6-4 on the season.
Beyond that, I believe the Rams are plenty good enough to make a Super Bowl run this year. They won it all in 2021 and have what it takes to do it again in 2025.
Prediction: Rams win 27-21
Detroit Lions @ Washington Commanders
Sunday, November 9th, 4:25 PM ET
The Washington Commanders have endured a season to forget thus far, and it might only get worse, as they welcome the Detroit Lions to town after getting blown out at home by the Seattle Seahawks in Week 9 on Sunday Night Football.
Jayden Daniels won’t be suiting up in this game due to the dislocated elbow he suffered, and if you ask me, he should be shutdown for the rest of the 2025 season, and the Commanders need to turn their attention to 2026.
What they’ve built is an old, bad, aging roster, and GM Adam Peters, outside of drafting Daniels, honestly hasn’t done a great job. This team needs a reset in the worst way to ensure their young QB can sustain success.
On the flip side, the Detroit Lions are coming off of a bad loss of their own, and it was at home against JJ McCarthy and the Minnesota Vikings. Frankly, the Lions should be ashamed of themselves for that loss, as the Vikings had no business winning that game.
I would bet on Dan Campbell’s crew responding well after a loss, and they get to beat up on a hurting team in Week 10. The Lions are going to come out swinging and will be able to make an impact on both sides of the ball.
Backup QB Marcus Mariota just isn’t going to be able to do enough, and it’s not like he’s got a great supporting cast around him, either.
Detroit wins this game by 16 points and improves to 6-3 on the season, while the Commanders unfortunately keep stacking losses.
It's going to be a long rest of the season for the Washington Commanders, but it's not time to make any major changes.
Prediction: Lions win 33-17
Pittsburgh Steelers @ Los Angeles Chargers
Sunday, November 9th, 8:20 PM ET
The Pittsburgh Steelers are in Los Angeles to face the Chargers in Week 10 on Sunday Night Football, and this game got a lot more interesting now that we know Joe Alt is going to miss the rest of the season with another ankle injury.
The Chargers beat the Tennessee Titans in Week 9, but they obviously lost Alt in the process and are now officially down their starting tackle duo, which was, arguably, the best in the NFL coming into the season.
Unless LA makes multiple major moves along the offensive line, which their GM clearly is not capable of doing, this team is going to suffer on offense. The franchise has been bitten by the injury bug this year to say the least.
Justin Herbert is again operating with a flawed supporting cast, but he’s not been that great this year. On the flip side, the Pittsburgh Steelers are coming off a great win over the Indianapolis Colts in Week 9 and can expose the Chargers’ bad offensive line in this one.
I would expect the Steelers’ pass rush to feast, as the Chargers' OL group may now be the worst in the NFL with the news that Alt is out for the rest of the season.
We’ve also seen QB Aaron Rodgers operate at a steady, efficient level in 2025, and it’s honestly quite impressive. Pittsburgh notches a score late in the fourth quarter to take the lead, and the Chargers are unable to drive down the field for a potential game-winning score.
LA would drop to 6-4 if this prediction holds, and the Steelers would improve to 6-3 and have their second win in a row after losing two in a row.
The Steelers are such an interesting team, and it would be the most ‘Steelers’ thing ever to win this thing in Week 10.
Prediction: Steelers win 24-23
Philadelphia Eagles @ Green Bay Packers
Monday, November 10th, 8:15 PM ET
The final game of the Week 10 slate sees the Philadelphia Eagles visiting the Green Bay Packers, and this game could have a huge impact on how the NFC playoff picture looks. Both Philly and Green Bay have not been great this year at times, as the Packers have tied the Cowboys and lost to the Carolina Panthers and the Cleveland Browns.
The Eagles have struggled with consistency on offense and have not had the easiest time on defense this year, either. Philly did recently swing multiple trades to try and improve on that side of the ball, but it’ll have to be a matter of time before we see if those additions pay off.
The Packers hope to get this bad taste out of their mouth in Week 9, as losing to the Panthers at home is just inexcusable.
Philly is well-rested coming out of their bye and might end up being favored slightly in this one. I would take the Eagles at first glance, as the Packers are just too up-and-down for me, and Philly did get on the right track, winning their last two games before the bye.
This was supposed to be a season where the Packers took that next step into contention, but we just have not seen it yet. As for Philly, all they have to do is likely win just a few more games, and they’ll likely again win the NFC East and be guaranteed a top-4 seed in the NFC playoffs and at least one home playoff game.
The Packers drop to 5-3-1 in this prediction, but the Eagles keep their winning streak alive and improve to 7-2, maintaining a realistic shot at the no. 1 overall seed in the NFC playoffs, but we do have a long way to go.