There are five games in the primetime slots this week. Let's make our picks and predictions for the primetime games. With two Monday Night Football games again in Week 6, there is a ton of primetime action coming in the latest week of NFL action. The league this year feels a bit more competitive, especially in the AFC.
It's really anyone's league at this point, and there are not more unbeaten teams - the Eagles and Bills were able to get to 4-0, but this is the quickest we have seen unbeaten teams fall in years now. Week 6, and frankly the rest of the 2025 NFL Season does promise to be just like this.
We have unveiled our picks and score predictions for the five primetime games in Week 6, including the international game in London between the Broncos and Jets. Let's get into our picks right here.
NFL picks and predictions for the five primetime games in Week 6
Thursday, October 9th
Philadelphia Eagles @ New York Giants, 8:15 PM ET
Both the Eagles and Giants have a short week, but it's Philly who has to do the traveling. The Eagles got embarrassed by the Denver Broncos in the fourth quarter in Week 5 and suffered their first loss of the season, and while that did leave a ton of questions for the team to answer, the New York Giants really do not stand a chance.
The Giants got beat up quite a bit by the New Orleans Saints, and while New York's pass rush is going to make life hard for Jalen Hurts, this game is going to be won by the Eagles.
Prediction: Eagles win 23-14
Sunday, October 12th
Denver Broncos @ New York Jets, 9:30 AM ET (London)
The Denver Broncos and New York Jets faceoff in London. The Jets are the lone winless team in the NFL, and Denver is riding a two-game winning streak. While many can see the possibility of this being a trap game for the Broncos, I believe this team is too good to let that happen right now. Sean Payton typically wins about 70% of his games in October and November, so this is when his teams heat up.
Prediction: Broncos win 31-20
Sunday, October 12th
Detroit Lions @ Kansas City Chiefs, 8:20 PM ET
The Kansas City Chiefs lost a double-digit lead to the Jacksonville Jaguars and are now 2-3 on the season. Many people had figured that KC was going to get heated up here and win their third game in a row after an 0-2 start, but that isn't the case.
The harsh reality with this team is that they simply aren't that special and are again going to lose. The Detroit Lions come to town, and they just might be the best team in football right now. They out-talent the Chiefs at most positions, and Kansas City just does not have the secondary to keep up with the Lions receiving weapons.
This game might even get out of hand a bit.
Prediction: Lions win 28-17
Monday, October 13th
Buffalo Bills @ Atlanta Falcons, 7:15 PM ET
The first of two Monday Night Football games in Week 6, the Buffalo Bills travel to face the Atlanta Falcons, who are coming off of their bye week. While the Falcons will be well-rested, the Bills usually rebound nicely after a bad loss, and I bet they do that this week. Atlanta is also pretty up-and-down, and you really just never know what you'll get from this team.
They've beaten the Vikings but have also gotten blown out by the Panthers. Buffalo wins this one and gets to 5-1. The Falcons drop to 2-3, but they should be able to move the ball.
Prediction: Bills win 28-23
Chicago Bears @ Washington Commanders, 8:15 PM ET
The Chicago Bears are another team coming out of their bye week in Week 6, and I think we can all remember the last time Washington and Chicago played. Something about a last-second Hail Mary rings a bell...
Anyway, the Bears are a better team now than they were in 2024, but I don't think that is going to change things here. Jayden Daniels is back and healthy and is going to propel this team to a solid 4-2 start, sending the Bears down to 2-3.