We can now turn to Week 5 of the 2025 NFL Season. Which teams are on heavy upset alert? Week 4 is already behind us, as we are making our way through the quarter-mark of the 2025 NFL Season. Week 5 is quickly approaching, and we have begun to see the hierarchy across the league take shape.
There are some clear-cut games on Week 5's slate that are good easy to predict, but there could be others that end up being unexpected and dramatic. We've identified three teams very much on upset alert approaching this week's contests.
Let's dive into those three teams and talk about why they should be on the lookout for a major upset.
2025 picks and score predictions for teams on upset alert in Week 5
Philadelphia Eagles (vs. Denver Broncos)
The Philadelphia Eagles are repeating their 2023 season - stacking wins by slim margins but not playing great football on either side. The offense is stuck in second gear - Jalen Hurts is not a high-end passer, the run game hasn't gotten going, and even the offensive line has struggled.
The entire operation just isn't consistent at all, and even the defense has lost some talent this offseason. Despite this, Philly has been able to win their first four games, but they have all been within a score, and oddly enough, their travel schedule has been 'back and forth' up to this point, so they haven't yet had two-straight games at home or on the road.
The Denver Broncos come into this game having won big-time over the Cincinnati Bengals and might have the right personnel on defense to again make Philly struggle on offense.
With Denver's run game slowly coming alive, the Broncos have the players and scheme to go into Philly and hand the Eagles their first loss of the 2025 NFL Season. It feels like both Philly and Denver are pretty evenly-matched despite the difference in records.
Prediction: Broncos win 23-21
Buffalo Bills (vs. New England Patriots)
The Buffalo Bills have a problem on the defensive side of the ball. Buffalo is a bit injured over there, but the defense also hasn't been that good for most of the season. Well, in Week 5, this team does have a pretty major test against the New England Patriots. Second-year QB Drake Maye has looked flat-out fabulous thus far. In fact, his numbers might be a lot better than you expect:
91/123 (74%)
988 yards
7 touchdowns
2 interceptions
109.4 rating
New England also has the 10th-best scoring offense and defense, so this team is legitimate. I would not gloss over the Pats, as they are a bit better than their record might indicate, and I would also be willing to say that the Bills might not be quite as good as their record indicates.
Buffalo has the 17th-best scoring defense in the NFL, allowing 22.5 points per game. This game has the chance to be a high-scoring affair, and New England is going to keep this game close. While I do believe the Bills close it out, it's going to be by a razor-thin margin.
Prediction: Bills win 28-27
Kansas City Chiefs (@ Jacksonville Jaguars)
The Jacksonville Jaguars have a great, explosive defense thriving off of takeaways. They are a better unit than the Kansas City Chiefs have on offense, so that's really the matchup for me in this one. The Jags get this game at home and are coming off of a solid win over the San Francisco 49ers.
The Chiefs have won their previous two games, but most can see just how shaky KC seems to be. The Jags are going to create some turnovers and will be able to steal a possession or two in this one, and they simply might be a very good team, period.
I would also expect Trevor Lawrence and the offense to settle in at home point. Give me Jacksonville at home.