A handful of teams could be on upset watch in Week 2 of the 2025 NFL Season. Let's talk about them right here.
Upsets are generally fun to experience, and there were a couple in Week 1. Now that we're in Week 2 already, there could be a few more. In fact, we've cooked up five potential upsets to keep an eye out for.
There are so many different factors that can contribute to an upset in today's NFL, and to be fair to even the worst teams in the league, there is talent present on those squads, and anything can happen in any given Sunday. Let's chat about five potential upsets in Week 2 of the 2025 NFL Season.
These five teams are on upset watch for Week 2 of the 2025 NFL Season
Cincinnati Bengals (vs. Jacksonville Jaguars)
One team that has started slow in recent years is the Cincinnati Bengals, but they did earn a hard-fought win in Week 1 over the Cleveland Browns. Well, the Jaguars put on a nice performance against the Carolina Panthers, and this could simply be a flat-out upset.
Zac Taylor's Bengals teams just can't shed the slow start, and just because they won the first game of the season, it doesn't mean they can't lose two or three in a row. Remember, this team won just four of their first 12 games in the 2024 NFL Season, so they could be due for a losing streak early on.
Chicago Bears (@ Detroit Lions)
The Chicago Bears and first-year head coach Ben Johnson are in Detroit and seeking to win a huge game against Johnson's old team. There seems to be a sour relationship now between Johnson and the Lions, and I am sure he'd love nothing more than to earn his first win against the team he used to coach.
Chicago did have a strong lead against the Minnesota Vikings before their fourth-quarter collapse, so it's not like this team can't hang around. Furthermore, the Lions got embarrassed by the Green Bay Packers in Week 1, so this team simply might not be nearly as good as we think.
I would keep an eye out for the Chicago Bears beating the Detroit Lions in Week 2.
San Francisco 49ers (@ New Orleans Saints)
Alright, so Brock Purdy is going to be missing a few games with a turf toe injury, which just is not ideal. The New Orleans Saints are again at home in this one and look to earn their first win of the season after a loss to the Arizona Cardinals in Week 1.
The Niners, top to bottom, are a better, more talented, and overall more well-run organization than the Saints, and that isn't even a question. And in today's NFL, the QB matchup is generally what decides things in the end.
With the 49ers set to start Mac Jones, the QB matchup got that much more even with Spencer Rattler of the Saints. If nothing else, the Saints' defense might be able to contain Jones and the 49ers' offense enough to earn the slim win and improve to 1-1.
Buffalo Bills (@ New York Jets)
Every one in a while, the Buffalo Bills get in their own way and just a game they absolutely should not have. Well, could this be one of them? Buffalo mounted an improbable comeback in Week 1 against the Baltimore Ravens, and it was an emotional win.
The Jets are going to be a non-factor in 2025; this team simply isn't good, so Buffalo should win this game, right? You can find examples over the recent years of Buffalo just dropping the ball and having one of those 'stinkers.' Week 2 against the Jets could be one of those games.
Denver Broncos (@ Indianapolis Colts)
The Denver Broncos blew out the Indianapolis Colts in Denver back in 2024, and the circumstances are a little bit different. The Colts now have Daniel Jones at QB and are getting this game at home. In Week 1, Indy blew out the Miami Dolphins, but the Broncos' defense is a different beast. On paper, the Broncos are clearly more talented than the Colts, and most people would predict Denver to win this one.
However, what if they don't?
What if Daniel Jones is actually a competent QB now and is good enough to lead Indy to a close win against a Broncos' team that has started slow under Sean Payton?