There are a handful of games in Week 5 that simply seem too easy to predict, as these teams are guaranteed to win. We have hit the quarter-mark of the 2025 NFL Season already, and we are beginning to see the hierarchy across the league take shape.
Just two unbeaten teams remain, as the Buffalo Bills and Philadelphia Eagles are atop of their respective conferences, but each team does have notable flaws. On the other side of things, the New Orleans Saints, New York Jets, and Tennessee Titans are the remaining winless teams in the league and don't really have much going for them at this point.
As we turn our attention to Week 5, we've identified five teams that have a guaranteed win on their schedule. Let's dive into those teams right here.
These five teams are guaranteed to win in Week 5
Los Angeles Rams (vs. San Francisco 49ers)
The LA Rams are coming off of a major win over the Indianapolis Colts, and the San Francisco 49ers come into this game having dropped their first of the season, a home game against the Jacksonville Jaguars, who are better than expected.
The 49ers are simply not in the same tier as the Rams - from the QB situation up to the head coach, the 49ers cannot matchup with the Rams, and San Fran is also dealing with, yet again, a ton of injuries, and that is putting it lightly.
It feels like the injury bug hits this team in a major way each year. The LA Rams are the healthier, better team and will get the job done.
Minnesota Vikings (@ Cleveland Browns)
You might be wondering why I'd guarantee the Minnesota Vikings, an average team, to win on the road against a stingy defense, as the last Browns' home game was a win over the Green Bay Packers, but the Vikings do respond well off of losses, as head coach Kevin O'Connell is simply better at this thing than most coaches in the league.
Minnesota does have the talent to overwhelm the Browns and snatch a lead in the second half.
Indianapolis Colts (vs. Las Vegas Raiders)
The Indianapolis Colts were 3-0 heading into Week 4 but are now 3-1 after a pretty sloppy loss against the Los Angeles Rams. LA was the best team the Colts had faced this year, and they could not get it done, so you do have to wonder just how high their ceiling can be. Well, Indy is back at home and hosting the lowly Las Vegas Raiders, a team riding a three-game losing streak.
Vegas dropped a heartbreaker at home against the Chicago Bears. Chicago blocked what could have been the game-winning field goal. What we know about each team is that the Colts have moved the ball quite easily this year, and the Raiders' defense is just bad.
Indy has too many talented players on the offensive side of the ball to keep track of, so the Raiders are going to get overwhelmed big-time in this one.
Arizona Cardinals (vs. Tennessee Titans)
The Tennessee Titans could end up being one of the worst teams in this recent 17-game era. They got shutout by the then 1-3 Houston Texans, so that tells you all you need to know about the Titans. The coaching staff is bottom-tier, and Cam Ward does look quite rough if you ask me.
The Cardinals are not a great team by any means, but they are definitely good at a few things, not a disaster by any means, and get this game at home. After a two-game losing streak, look for the Cardinals do bounce-back with a rock-solid win against a horrendous football operation.
Detroit Lions (@ Cincinnati Bengals)
The Cincinnati Bengals might not win another game in 2025 unless they make a major move at the QB position, but this year feels lost already - Joe Burrow is likely not returning this year, and the Bengals have a ton of issues outside of their oft-injured QB.
The Detroit Lions have won three games in a row and are back to blowing opponents out, and I am not exaggerating when I say that the Lions might hang 50 points on the Bengals in Week 5 - it's going to be a blowout of epic proportions.