Week 4 of the 2025 NFL Season is right around the corner. Let's make our picks and score predictions for primetime matchups. There are four primtime matchups this week with Thursday and Sunday Night Football, and two Monday Night Football games.
It's wild to think that Week 4 already brings us to the quarter point of the 2025 season, but here we are. In the coming weeks, the league is going to continue to shake out, as the season progressing will show us which teams are truly contenders or not.
There are some very competitive games expected to be played in Week 4, so let's give our picks and score predictions for all four primetime matchups.
NFL picks and score predictions for primetime matchups
Thursday Night Football - Seattle Seahawks @ Arizona Cardinals, 8:15 PM
In an NFC West battle, the Seattle Seahawks are in Arizona to face the Cardinals. Both Seattle and Arizona are 2-1 on the year and are looking to advance to 3-1. What sticks out to me most about this matchup is just how intense the Seahawks' defense is. Further, I am not sure the Cardinals have enough 'oomf' on offense to compete with Seattle's aggression on the other side of the ball.
The QB matchup between Sam Darnold and Kyler Murray might be a wash, as well, so look for the Seahawks to win this one.
Prediction: Seahawks win 24-16
Sunday Night Football - Green Bay Packers @ Dallas Cowboys, 8:20 PM
This Sunday Night Football game is going to be intense, as it's a quick homecoming for Micah Parsons, who was obviously traded from Dallas to Green Bay before the regular season. From top to bottom, the Packers do have the advantage, and this game is going to go as expected. Green Bay is going to bounce back from their ugly loss at the Cleveland Browns and get to 3-1 on the season.
Prediction: Packers win 30-20
Monday Night Football - New York Jets @ Miami Dolphins, 7:15 PM
What did we do to deserve this matchup? It's a game between two of the five worst teams in the NFL. The New York Jets are in Miami to face the Dolphins, and both teams reek of desperation for a win at this point. However, the differences between the two franchises is obvious. The Jets regime is in year one, so they're likely going to be afforded some time to get this thing right and aren't expected to win a ton this year.
On the flip side, this Miami Dolphins' regime is clearly on its last legs and have to begin stacking wins now.
A home loss against the lowly Jets might call for some major change. On paper, the Dolphins do have a better chance at winning, as they are still able to push the ball down the field and create explosive plays when needed, and no matter who is under center, Miami has the QB advantage, so I would take the Dolphins here at home.
Prediction: Dolphins win 28-18
Monday Night Football - Cincinnati Bengals @ Denver Broncos, 8:15 PM
If there was ever such a thing as a 'get right game' in the NFL, the Denver Broncos have been gifted one. Before the regular season began, this was primed to be one of the games of the year, but the Broncos have looked sloppy thus far, and the Bengals do not have Joe Burrow.
The Broncos have played quite terribly over the past two weeks but have needed their opponents to kick a walk-off field goal to win, so I guess there's a small silver lining there. The Bengals are simply now a bottom-tier team without Burrow, so with Denver returning home for the first time since Week 1, I reckon that they'll have their best foot forward and play the most complete game they have in quite some time.