Sep 22, 2013; New Orleans, LA, USA; New Orleans Saints Saintsations cheerleaders perform during the second half of a game against the Arizona Cardinals at Mercedes-Benz Superdome. The Saints defeated the Cardinals 31-7. Mandatory Credit: Derick E. Hingle-USA TODAY Sports

The New Orleans Saints are coming off of their BYE week and they will be taking on the Buffalo Bills. It doesn’t sound like C.J. Spiller will be playing in this game, so Fred Jackson will get a lot of the action out of the backfield for the Bills. The Bills will also have Thad Lewis taking control under center again. The New Orleans Saints should be well rested for the game. They have had a lot of time to think about that loss that they gave away to the Patriots and they will be looking to finish their game off this time around.

Where: Mercedes-Benz Superdome, New Orleans, LA

When: October 27, 2013, 1:00 p.m. ET

Watch: CBS

Live Stream: NFL Sunday Ticket, Game Rewind

Bills Player to Watch: Thad Lewis

Oct 20, 2013; Miami Gardens, FL, USA; Miami Dolphins cornerback Dimitri Patterson (24) sacks Buffalo Bills quarterback Thad Lewis (9) in the second half at Sun Life Stadium. Mandatory Credit: Robert Mayer-USA TODAY Sports

Even with the injuries at the quarterback position, the Bills have been able to keep their games competitive. Thad Lewis has been a big reason for that. Lewis has done well in the absence of EJ Manuel. He has completed 62.5 percent of his passes for 418 yards and a couple of touchdowns.

Saints Player to Watch: Drew Brees

Oct 13, 2013; Foxborough, MA, USA; New Orleans Saints quarterback Drew Brees (9) reacts during the second half of a game against the New England Patriots at Gillette Stadium. Mandatory Credit: Mark L. Baer-USA TODAY Sports

How will the Saints bounce back after that tough loss to the Patriots. It will be up to Brees to get this team rolling out of the gate and put that game on the back burner. Brees is one of the league leaders in passing with 1958 yards passing for 14 touchdowns.

Prediction:

Sep 30, 2013; New Orleans, LA, USA; New Orleans Saints fans celebrate after a touchdown in the second half against the Miami Dolphins at Mercedes-Benz Superdome. New Orleans defeated Miami 38-17. Mandatory Credit: Crystal LoGiudice-USA TODAY Sports

The Saints are at home and they are looking to get that bad taste out of their mouth. They are coming off of a BYE week and they will be rolling in this game. Drew Brees and the offense will have the ball moving up and down the field and the Saints will come back strong.

Saints 35, Bills 20