DraftKings NFL picks, Week 10: Best DFS picks and lineup

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Score big on your DraftKings NFL picks for Week 10 by following this DFS fantasy football advice and constructing the perfect lineup to win.

Whenever you have a slate of games where there are a ton of teams on bye, that makes coming by DraftKings NFL picks and constructing a winning DFS fantasy football lineup all the more difficult. It’s also the reality of the situation for anyone looking to play in Week 10 as there are six teams on a bye.

It’s also an interesting week for DraftKings DFS players as the NFL gets Patrick Mahomes back this week, immediately making him one of the top options. Furthermore, Christian McCaffrey is now priced absurdly high, reaching five figures if you want to put him in your DraftKings NFL lineup for Week 10.

Thus, you have to find the right bargains and build the right lineup around all that’s happening. We’re here to help with that, going position-by-position and looking at the best options for DraftKings NFL picks and then constructing a winning lineup to play (or so we believe).

Let’s start with the quarterbacks.


Lamar Jackson, BAL (at CIN), $7,300 – After helping to topple the Patriots, Jackson now leads Baltimore to face the lowly Bengals for the second time this season. Though he’s been battling an illness all week, Jackson should dominate if he takes the field in Week 10.

Patrick Mahomes, KC (at TEN), $7,000 – Do we know what Mahomes is going to look like as he plays his first game coming back from a dislocated kneecap? Not in the slightest. But does anyone want to bet against Mahomes? Same answer as before.

Drew Brees, NO (vs. ATL), $6,700 – The only danger about starting Brees in your DraftKings lineup is that he might not be on the field for the majority of the second half. Even still, he has the potential to light up a bad Falcons defense early and still be a worthwhile start.

Kyler Murray, ARI (at TB), $6,500 – Murray is a better option than Jameis Winston for me because I believe in him in regards to throwing fewer turnovers. Regardless, this game is going to be pass-happy for both teams and Murray could wind up throwing a ton to try and keep up with the Bucs.

Matt Ryan, ATL (at NO), $6,100 – Though the Falcons are quite bad, Matt Ryan has been a reliable fantasy play all season, particularly in DFS where Atlanta’s struggles have knocked down his price. I love this likely game script and his production as he gets back on the field.

Ryan Tannehill, TEN (vs. KC), $5,100 – Quietly, Tannehill has been around 20 fantasy points in each of his starts with the Titans. He’s now going up against a Chiefs defense that is both generous and likely to have to defend the pass a ton now that their offense is back at full strength. This is a sneaky-great value on DraftKings.

Ryan Finley, CIN (vs. BAL), $4,800 – The flier to end all fliers, if you actually believe that Andy Dalton was the problem with the Bengals, you could save a ton of money by putting Finley into your lineup.