2021 NFL picks, score predictions for Week 6

Oct 3, 2021; Inglewood, California, USA; Arizona Cardinals quarterback Kyler Murray (1) moves out to pass against the Los Angeles Rams during the first half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports
Oct 3, 2021; Inglewood, California, USA; Arizona Cardinals quarterback Kyler Murray (1) moves out to pass against the Los Angeles Rams during the first half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports /
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Jay Biggerstaff-USA TODAY Sports
Jay Biggerstaff-USA TODAY Sports /

Buffalo Bills (4-1) at Tennessee Titans (3-2)

Monday, October 18, 8:15PM ET

Right now, the Buffalo Bills are among the most dangerous teams in the NFL. After thrashing three teams in a row, they took it to Mahomes and the Chiefs in primetime and have proven they can beat a quality team. I’m sure doubters remain, but I’m buying Buffalo.

Even more so against a Tennessee Titans team that, let’s be honest, hasn’t lived up to their 3-2 record so far. Their defense has been abysmal at times, their offensive line is a mess, and they could probably be as bad as 0-5 if it wasn’t for Derrick Henry. To say things haven’t gone as planned in Tennessee would be an understatement.

On Monday night, we’ll see just how bad things have gotten for the Titans. The Bills are going to run them over, throw in reverse, and run them over again while burning rubber on their flatten confidence. It’s going to be an ugly game.

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Next. NFL Power Rankings, Week 6: Bills own AFC, Cowboys surging. dark

Josh Allen might even be on the bench by the time this one is done. The Tennessee defense is going to learn firsthand how hard is to slow down the Bills, while their offense meets a brick wall. Henry might have some success, but there won’t be many points for the Titans.

Prediction: Bills win 38-13 | Spread: Bills (-5)