2021 NFL picks, score predictions for Week 10

Carolina Panthers (4-5) at Arizona Cardinals (8-1)

Sunday, November 14, 1PM ET

It doesn’t matter what is thrown the Arizona Cardinals’ way — no Kyler Murray, no DeAndre Hopkins, no problem. Even without their top receiver and with Colt McCoy under center, the Cardinals took care of business in Week 9 and are still looking like the cream of the NFC crop.

It makes me all the more confident in this pick when you consider that the Carolina Panthers have been stumbling and bumbling their way through the last few weeks. Even with Christian McCaffrey back in the mix, the Panthers couldn’t get anything going on offense in Week 9. I’d expect similar results in Week 10 against the Cardinals.

The Arizona defense has another big game, getting after Sam Darnold all game long. Especially if Murray can return to the lineup, the Cardinals should also be able to score early and often, even against a quality Carolina defense.

It’s been a rough second quarter of the season for the Panthers, and that’s not going to change in Week 10. Carolina visits the desert and gets crushed, further hurting their chances of even tasting the postseason after starting the season 3-0.

Prediction: Cardinals win 34-10 | Spread: Cardinals (-10)