2021 NFL picks, score predictions for Week 10

Los Angeles Rams (7-2) at San Francisco 49ers (3-5)

Monday, November 15, 8:15PM ET

Oh my. What happened to the Los Angeles Rams this past Sunday was an embarrassment. For one of the most offensively gifted teams in the NFL, they looked completely lost. If it wasn’t for their defense, the Rams may have lost by 40 in that miserable excuse for a game.

Fortunately for Los Angeles, things are destined to turn around in Week 10. They’ve got an underwhelming, injury-riddled San Francisco 49ers team hosting them, and chances are they avoid starting a losing streak of their own. The Rams are still one of the best teams in the NFC, and we’ll see evidence on that on Monday night.

It’s not like the 49ers have been anything exciting this season. Injuries haven’t helped, but the ground game is bipolar and the turnovers come too often in the passing game. Jimmy Garoppolo has never been a star, and his inability to consistently strike paydirt has been hurting San Francisco in 2021.

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Cooper Kupp turns it up to 12, and Matthew Stafford snaps out of whatever daze he was in against the Titans. The Rams roll over the 49ers and remain in the hunt for the top spot in the NFC.

Prediction: Rams win 36-23 | Spread: Rams (-4)