2021 NFL picks, score predictions for Week 11

Arizona Cardinals (8-2) at Seattle Seahawks (3-6)

Sunday, November 21, 4:25PM ET

The Arizona Cardinals need Kyler Murray back in the worst of ways. Three early turnovers in Week 10 basically dug Colt McCoy and Co. into a hole they couldn’t find their way out of, and it’s clear McCoy isn’t the answer against quality defenses.

That’s what the Cardinals will face again in Week 11 when they head north to take on the Seattle Seahawks. While the Seahawks’ record isn’t impressive and some numbers suggest the Seattle defense isn’t great, they’ve perfected the bend without breaking approach. It won’t be easy to find the end zone on Sunday, especially if Murray can’t go.

Considering Murray was bouncing around ahead of the Cardinals’ Week 10 outing, there’s optimism he’ll be ready to go. And if that’s the case, I’m giving this one to Arizona. Between Murray and James Conner, they shouldn’t have too much trouble putting points on the board. If Murray can’t go, though, it may be a different story.

For now, we’ll assume Murray is on the field. That’ll mean points for the Cardinals. And seeing as Russell Wilson looked like a shell of his former self in his return to the field, I’m thinking the Seahawks offense is sluggish and fails to match Arizona in the points department.

Prediction: Cardinals win 36-25 | Spread: Cardinals (-2.5)