2021 NFL picks, score predictions for Week 11

Indianapolis Colts (5-5) at Buffalo Bills (6-3)

Sunday, November 21, 1PM ET

I like what the Indianapolis Colts have done over the last few weeks. Jonathan Taylor is emerging as one of the league’s top running backs, and Carson Wentz is finally playing like the quarterback the Colts thought they were getting. However, that won’t be enough in Week 11.

When the Buffalo Bills are on top of their game, they’re one of the most dangerous teams in the NFL. Josh Allen is an electric presence under center, they’ve got plenty of weapons on offense, and their defense is among the opportunistic we’ve seen this season. As it turns out, that could work out in the Bills’ favor against Indy.

Wentz has been great down the stretch but he also has a tendency to take too many risks. The Bills defense loves to capitalize on silly mistakes and will do exactly that on Sunday. Every time we see Wentz toss up a prayer, expect it to go the other way before the whistle blows.

Allen has another big game, and Devin Singletary gets it going on the ground as well. The win, however, goes to the Bills defense, which makes life miserable for the Colts and keeps Taylor from going off the way he’s done the last few weeks.

Prediction: Bills win 34-21 | Spread: Bills (-6.5)