2021 NFL picks, score predictions for Week 16

Indianapolis Colts (8-6) at Arizona Cardinals (10-4)

Saturday, December 25, 8:15PM ET

Right now, the Arizona Cardinals are caught in a downward spiral. They’re coming off an ugly loss to the Lions, who walked away with only their second win on the season. they’re expected to take on the surging Indianapolis Colts who are hungry to improve their playoff chances? Yikes.

If the Cardinals couldn’t slow Jared Goff, they’re going to have a bad time trying to keep Carson Wentz, Jonathan Taylor, and the Colts’ offense in check. Indianapolis is already coming off a momentum-boosting win against the Patriots and will be riding a high that should help them take care of Arizona.

Plus, the Cardinals have not been good at home this season. They seem to forget who they are when playing at State Farm Stadium. Then again, they forget who they were last week on the road as well. Either way, it’s looking like they’re going to need to reset before the playoffs start to regain some of their shine.

It’s not going to happen this week, though. The Colts come into town and get the job done, running the ball down the Cardinals’ throats and punching the Arizona offense in the mouth. They create at least two turnovers and come away with a comfortable win.

Prediction: Colts win 34-23 | Spread: Cardinals (-1.5)