FanDuel NFL picks, Week 16: Best FanDuel DFS Lineup

Photo by Ronald Martinez/Getty Images
Photo by Ronald Martinez/Getty Images /
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FanDuel DFS NFL Week 16 picks and lineup advice: Tight End

Mark Andrews ($8000) is on an absolute tear as of late, which is a trend that looks to continue against a Bengals team that is the worst in the league at guarding the tight end. With all the cheap running backs, Andrews should be a goal of yours in your cash lineups.

Rob Gronkowski ($6700) is also a fantastic play, as he could be in for double-digit targets with the three top targets on the Bucs gone.

I also like Dawson Knox ($6100) without Gabriel Davis and Cole Beasley and I think he finds the end zone this week as the Bills look to avoid repeating what happened last time they played the Patriots.

My favorite cheap plays of the week are James O’Shaughnessy ($5300) and Cole Kmet ($5000), who have both seen their targets increased as of late and both have favorable matchups. Of the two I prefer O’Shaughnessy who should be the Jaguars’ number two target with Laviska Shenault on the COVID list.

FanDuel DFS NFL Week 16 picks and lineup advice: D/ST

My favorite play at defense this week is Atlanta ($3800) as I think they handle business against whoever it is that starts at quarterback for the Lions, holding them under two touchdowns and snagging a few turnovers in the process.

However, if you want to play a stronger defense at the same price, Denver ($3800) has been a very solid defense and gets to face a Raiders team with no real offensive identity these past few weeks.

While I do not want to go any lower than that, I do like both Buffalo ($4000) and New England ($4100), who are two solid defenses that should be able to shine in what I project to be a low scoring affair.

FanDuel DFS NFL Week 16 Lineup

  • QB Justin Herbert – $8400
  • RB Alexander Mattison – $5500
  • RB Ronald Jones II – $5400
  • WR Cooper Kupp -$9800
  • WR DK Metcalf – $6700
  • WR Antonio Brown – $7000
  • TE Mark Andrews – $8000
  • FLEX Justin Jackson – $5400
  • D/ST Denver – $3800

I will be the first to admit that this is about the most popular lineup you can make, but I also fully believe that this is the way to play this week. The only way to get up to players like Kupp and Andrews is to save up at running back, and while you do not need to play all three, you will likely need to decide on two for your cash lineup.

However, for tournament formats, I actually recommend fading some of these plays. While the running backs will all likely provide good value, this does not mean they will be the three best plays on the slate.

Play a more expensive running back like Joe Mixon and save up at wide receiver with some deep shots like Van Jefferson and Emmanuel Sanders and play a riskier lineup and hope the more popular plays flop. Regardless of your eventual lineup, best of luck in your Week 16 DFS endeavors, and Happy Holidays!