2022 NFL picks, score predictions for Wild Card Round

 No. 6 San Francisco 49ers (9-7) at No. 3 Dallas Cowboys (12-5)

Sunday, January 16, 4:30PM ET

There’s going to be at least one upset on Wild Card weekend, and chances are it comes from this game. While the Dallas Cowboys have been great at times this season, they’re beatable — especially against an opponent as well-rounded and consistent as the San Francisco 49ers.

Sure, Dak Prescott is coming off a five-touchdown game and confidence is high. However, they seem to stumble when the pressure is on and they’re forced to slow down electric playmakers. That’s exactly what the 49ers have in Deebo Samuel, who has been one of the scariest weapons in the NFL this season.

I’m just not sure the Dallas defense has what it takes to slow the 49ers down. Between Samuel, George Kittle, Elijah Mitchell, and Jauan Jennings, San Francisco seems able to move the ball with ease. The Cowboys’ defense is exceptional, but it’s going to have its hands full in this one.

I’m predicting Prescott has one of his down games as the Cowboys have a hard time producing points against the 49ers feisty defense. A big game from Samuel allows San Francisco to score at will, and the lower seed comes away with a not-so-surprising upset.

Prediction: 49ers win 35-21