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2023 NFL picks, score predictions for Week 2

BySayre Bedinger|Sep 12, 2023, 7:00 AM EDT

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Sep 10, 2023; Pittsburgh, Pennsylvania, USA; San Francisco 49ers running back Christian McCaffrey (23) runs with the ball against the Pittsburgh Steelers during the second half at Acrisure Stadium. Mandatory Credit: Gregory Fisher-USA TODAY Sports

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NFL picks — NFL picks Week 2

Seattle Seahawks (0-1) @ Detroit Lions (1-0)

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© 2026 Minute Media - All Rights Reserved. The content on this site is for entertainment and educational purposes only. Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands. All picks and predictions are suggestions only and not a guarantee of success or profit. If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER.