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2026 NFL picks and score predictions for every game in Week 5

Let's make our picks for Week 5!
ByLou Scataglia
Dallas Cowboys quarterback Dak Prescott
Dallas Cowboys quarterback Dak Prescott | IMAGN IMAGES via Reuters Connect
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Sunday, October 11th

San Francisco 49ers @ Seattle Seahawks, 4:25 PM ET

Oh boy, will this be a fun game or what? The undefeated San Francisco 49ers and 3-1 Seattle Seahawks square off in what could turn out to be a major NFC West showdown. The Niners are somehow 4-0 on the season despite dealing with a ton of injuries, but you’d never guess it with how well Brock Purdy and the defense have been playing.

And when you think about it - if this team can get healthy down the stretch, just imagine how good they can be. It feels like everything is working for the 49ers, and you struggle to see when this team is going to lose their first game.

As for the Seahawks, this team has been on a bit of a rollercoaster ride. Drew Lock filled in nicely for Sam Darnold, and while the Seahawks dropped a rather ugly Week 3 game against Washington, they bounced back nicely against the Chargers.

This truly feels like a back and forth game - both teams are perfectly capable of racking up a ton of points and doing multiple things well. Ultimately, this could come down to the coaching and the QB play, which is usually how it works when two juggernaut teams are facing each other.

While Mike Macdonald could be viewed as a better head coach than Kyle Shanahan due to his winning a Super Bowl, Shanahan is definitely more established and has been able to guide multiple 49ers teams through tough injury situations.

I believe the 49ers win this game by a field goal in a very classic game, as a 27-24 result really would not be a shock, as both offenses can be explosive, and both defenses can step up. Give me the Niners in this one.

Prediction: 49ers win 27-24

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