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2026 NFL picks, score predictions for every Week 10 game

Week 10 NFL picks and score predictions
BySayre Bedinger
Cincinnati Bengals quarterback Joe Burrow
Cincinnati Bengals quarterback Joe Burrow | USA TODAY Network via Reuters Connect
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The 2026 NFL season continues to truck along at a pace that is getting extremely uncomfortable. How in the world are we already at the NFL trade deadline?

The deadline itself is going to make the upcoming slate of games even more fascinating. As division races heat up, some teams are trying to separate from the pack, while others are trying to play catch-up.

The Week 10 schedule will be the NFL world's first national exposure to Bengals quarterback Joe Burrow, who hasn't played a single primetime game yet this season. And his first primetime game just so happens to be in a division showdown for 1st place against the Steelers.

This lineup of games also includes a huge matchup overseas between the Patriots and Lions, a lot of teams on upset alert, and the next chapter of the Packers-Vikings rivalry. Let's get into our weekly game picks and score predictions.

2026 NFL picks and score predictions for every Week 10 matchup

Teams on a bye: Broncos, Bears, Eagles, Buccaneers

Washington Commanders (2-5-1) @ New York Giants (5-2-1)

Thursday, November 12, 8:15 PM ET

We start off Week 10 action with a Thursday night NFC East showdown between the New York Giants and Washington Commanders, and this game is a lot more interesting than it may seem on the surface.

Even if the Giants become buyers at the NFL trade deadline, it doesn’t feel overly likely that we’ll see any new additions playing in this game, but it’s possible that New York’s roster could look substantially different – at least in some way – than it does at the time this post is being written.

Still, any acquisitions right now won’t likely change our prediction or thoughts on this game.

The Washington Commanders have been situationally inept so far this season. That’s the biggest reason why there is a “1” in the ties column of each team’s record here. The Commanders completely botched an end-of-game situation in overtime against the Giants earlier this season, and these two teams are a lot more evenly-matched than their records would indicate.

The oddsmakers in Vegas agree. New York is only favored by 1.5-points at home, which is basically an indicator that they feel this game is a toss-up. And especially given the injury JJ McCarthy is dealing with (hip), it feels like this game could go either way.

I’ll take the Giants playing at home in another low-scoring battle.

Prediction: Giants win 20-16

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