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2026 NFL picks, score predictions for every Week 10 game

Week 10 NFL picks and score predictions
BySayre Bedinger
Cincinnati Bengals quarterback Joe Burrow
Cincinnati Bengals quarterback Joe Burrow | USA TODAY Network via Reuters Connect
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New England Patriots (5-4) vs. Detroit Lions (6-2)

Sunday, November 15, 9:30 AM ET (game being played in Germany)

This season has definitely been a struggle for the New England Patriots. The reigning AFC champs were able to overcome a tough loss in Week 1 (and a 1-2 start to the season) to get to 5-3 heading into Week 9 action.

And then the Green Bay Packers came to town and absolutely blew them out of the water. 

The Patriots have been exposed in two of their last three games against NFC North teams. Drake Maye has turned the ball over a ton this season, especially playing against some of the better-coached teams in the league. 

Playing in Germany, the Detroit Lions are going to look to hand the Patriots their fourth-straight NFC loss this season. The Detroit defense has picked things up considerably after a rough start to the season. Getting Brian Branch back has been massive for this team, but the absence of Jack Campbell definitely looms large as the season keeps rolling along.

This game is tied for the highest over/under on total points (51.5) of any game on the slate in Week 10. The oddsmakers are expecting a bit of a high-scoring game, and that’s understandable.

This has the feel of one of those games where you expect it to be tight, but one team absolutely crumbles, makes a bunch of mistakes, and the other team wins it running away. That’s what I’ll be expecting. 

The Lions are 3-point favorites on a neutral field, but I’m going to call a bit of a blowout in this one. It could be either team, but recent weeks tell me it’s going to be the Lions.

Prediction: Lions win 34-20

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