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2026 NFL picks, score predictions for every Week 10 game

Week 10 NFL picks and score predictions
BySayre Bedinger
Cincinnati Bengals quarterback Joe Burrow
Cincinnati Bengals quarterback Joe Burrow | USA TODAY Network via Reuters Connect
7 of 14

Miami Dolphins (1-7) @ Indianapolis Colts (2-7)

Sunday, November 15, 1:00 PM ET

And here it is. This is the game and matchup everyone has been waiting for all season long. The only question is: How did this one not get flexed into the Sunday Night Football slot?

Is that laying it on too thick?

All kidding aside, there are major implications from this matchup between the 1-7 Dolphins and 2-7 Colts, and they are all of the 2027 NFL Draft variety.

Let’s start with the Dolphins, who are in contention for the #1 overall pick right now. A loss to the Colts would obviously keep the Dolphins on pace for one of the top 3 overall picks in next year’s draft, while a win is effectively a loss for them, at least in a way.

Not only would a win by the Dolphins hurt their own future NFL Draft positioning, but it would also improve one of the top picks for their division rival New York Jets. The Jets own the Colts’ 1st-round pick after the Sauce Gardner trade last year, so Jets fans are going to be actually rooting for the Dolphins in this game. 

Yes, there is an actual game to be played and there are actual matchups to be broken down, but these are two teams purely in evaluation mode at this point. Fantasy football players will be keeping tabs on this game, but how different will these rosters look come Sunday afternoon?

We’ve been asking that for a number of teams ahead of Week 10, but these two teams could be sellers, especially the Colts. Will Jonathan Taylor be on another roster? 

Indianapolis, playing at home, is just a 2.5-point favorite over Miami. If the Colts end up trading Jonathan Taylor, I’m going with a Dolphins upset in an ugly one.

Prediction: Dolphins win 23-19

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