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2026 NFL picks, score predictions for every Week 10 game

Week 10 NFL picks and score predictions
BySayre Bedinger
Cincinnati Bengals quarterback Joe Burrow
Cincinnati Bengals quarterback Joe Burrow | USA TODAY Network via Reuters Connect
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Carolina Panthers (3-5) @ New Orleans Saints (3-5)

Sunday, November 15, 1:00 PM ET

The battle for NFC South supremacy is going down in New Orleans this weekend. It’s wild to think about how significant one of these teams leaving Week 10 with a 4-5 record would be, but it also can’t be overstated.

The New Orleans Saints hung on for a win against the Cleveland Browns this past weekend, and the running game got a much-needed jolt from Audric Estimé. Jordyn Tyson made his debut (and took his lumps) in Week 9, and the Saints will have to keep getting him involved so he can be an impact player for them with the division on the line.

The Panthers are coming off a tough loss at home against the Denver Broncos in which Bryce Young played some of the best football we’ve seen from him all season.

And considering some of the numbers he’s been putting up, that’s really saying something.

With the way both of these teams are capable of putting up points offensively, it wouldn’t shock me to see this game be an absolute shootout in the Superdome. 

The Saints are favored by 1.5 points at home, which essentially means this game is viewed as a toss-up. Nobody knows where to plant their flag with either of these two teams right now, and that’s understandable.

These teams know each other well, and the Panthers have one of the most banged-up defenses in the league. We’ll see what the week brings in terms of injury news, but for now, I’ll lean slightly in favor of the home team. 

Prediction: Saints win 33-31

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