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2026 NFL picks, score predictions for every Week 6 game

Picks and predictions for every game in Week 6
BySayre Bedinger
Kansas City Chiefs QB Patrick Mahomes and Los Angeles Chargers QB Justin Herbert
Kansas City Chiefs QB Patrick Mahomes and Los Angeles Chargers QB Justin Herbert | USA TODAY Sports via Reuters Connect
10 of 14

Arizona Cardinals (1-4) @ Los Angeles Rams (2-3)

Sunday, October 18, 4:05 PM ET

The Arizona Cardinals are who we thought they were. You hate to see it.

The Cardinals have been in some tighter games this year than expected. They started off the season by beating up on the Los Angeles Chargers, but the Chargers are now 0-5 and the luster of that one has worn off a bit. 

Arizona simply doesn’t have the talent to be able to match up against most teams, but you never know when the stars are going to align. I’m not expecting it to be on Sunday against the Los Angeles Rams.

There really isn't much to say after the Rams' loss against the Buffalo Bills except that you'd hate to be the team now standing in their way with the chip that is now going to be on their shoulders.

I'm fully expecting Matthew Stafford and the Rams' offense to take out their frustrations after a brutal Monday night loss against the Bills on Arizona. Sean McVay won't take his foot off the gas.

The Rams are early 12.5-point favorites in this one. Given the fact that they’re playing at home, you absolutely expect them to deliver a blowout win and push the Cardinals one step closer to playoff elimination. 

Prediction: Rams win 34-20

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