2020 NFL picks, score predictions for Week 10

Indianapolis Colts (5-3) at Tennessee Titans (6-2)

Thursday, November 12, 8:20PM ET

In the first matchup between the two top dogs in the AFC South, we could get one of the best Thursday Night Football games of the year. These two teams have been kind of hard to figure out, but both offer the potential to light it up on any given night.

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In this one, I’m foreseeing a hard-nosed, low-scoring battle between these divisional rivals. The Indianapolis Colts boast a defense that doesn’t budge, as it’s currently ranked first in the NFL and third against the run. The Titans defense isn’t as stout, but their offense is far more explosive and less mistake-prone.

So what it’ll come down to is two things: can Philip Rivers avoid costly mistakes and can the Titans get Derrick Henry going against the Colts’ stingy defense? Honestly, I wouldn’t be surprised if neither happened. In that case, it’ll be up to Ryan Tannehill to secure the win for Tennessee.

If that’s the case, then the Titans should come away victorious. They may not be the most well-rounded team, but they’ve proven time and time again this season that Mike Vrabel has prepared them to weather the storm and come out on top. That happens again in Week 10, as they widen their lead in the division.

Prediction: Titans win 33-27