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2026 NFL Predictions, Week 10: Picks and predictions for each primetime game

Let's pick the primetime games. T
ByLou Scataglia
New England Patriots quarterback Drake Maye
New England Patriots quarterback Drake Maye | IMAGN IMAGES via Reuters Connect
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If you include the international game in Germany this week, the Week 10 slate does have four primetime games. We are late enough in the season to where these games will begin to have playoff implications, so keep an eye out for that.

And some of the primetime games this week could be very consequential for the playoff races when December and January roll around. As we have done each week, we've isolated the primetime games and have put our focus on them here.

Let's make our picks and score predictions for the four primetime games this week.

Week 10 NFL Predictions: Game picks for all four primetime games

Thursday, November 12th

Washington Commanders @ New York Giants, 8:15 PM ET

The Washington Commanders actually have the quarterback advantage here, but the Commanders are the far worse team, and games are usually decided by more than just the QB. Washington has had a season to forget and just don't do much of anything right. Head coach Dan Quinn has clearly lost his grip on his second head coaching stint. The New York Giants are in an opposite situation, though, as John Harbaugh has been stellar this year, and while the Giants also don't do anything exceptionally well, they also do not do anything that poorly, either.

I believe the Giants take care of business at home in a low-scoring game.

Prediction: Giants win 20-17

Sunday, November 15th

New England Patriots vs. Detroit Lions, 9:30 AM ET (Germany)

This could be a fun game, but there is a clear team that sticks out as being better. The New England Patriots are coming off a massive, inexcusable loss at home to Green Bay in Week 9, and they arguably face a better team in Week 10. The Pats are banged up as well, and we have seen QB Drake Maye beat up on the Pats' weaker opponents this year while struggling against the better ones.

On the flip side, the Detroit defense has played a lot better the past month, and Jared Goff has been a top-5 QB in the sport this year. The Lions put up a ton of points and win this one.

Prediction: Lions win 28-20

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