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2026 NFL picks and score predictions for each Week 6 primetime game

Our picks and predictions for Week 6's primetime games.
ByLou Scataglia
Denver Broncos head coach Sean Payton
Denver Broncos head coach Sean Payton | IMAGN IMAGES via Reuters Connect
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If you count the London game in Week 6 of the 2026 NFL Season, we have four primetime games, and with November and December right around the corner, the NFL will deploy even wackier game scheduling.

We're beginning to get late enough in the season to where games are having more at stake. The playoff race will truly begin to heat up in November and December, and the league does feel wide open this year.

Let's roll out our picks for all four of Week 6's primetime games here in 2026.

2026 NFL Season, Week 6: Picking each primetime game winner

Thursday, October 15th

Seattle Seahawks @ Denver Broncos, 8:15 PM ET

This could have been last year's Super Bowl had Bo Nix not broken his ankle in the Divisional Round. The Denver Broncos get this game at home, and they have gone 16-3 at home in the Nix era, which almost feels like a fake stat.

Seattle comes into this game having shown signs of regression. The offense hasn't been quite as good, and while the defense is still excellent, it doesn't have that 'bite' that it had last year. Honestly, both the Seahawks and Broncos don't feel quite as good this year as they were last year.

And with this game being in Denver, the Broncos should be able to win this one. They were able to comeback and beat Jacksonville and the Los Angeles Rams at home in Weeks 2 and 3, and I am not sure Seahawks quarterback Sam Darnold is particularly close to being as good as Trevor Lawrence or Matthew Stafford, so that's something to watch out for.

With two stingy defenses and offenses that have struggled, this should be a low-scoring game.

Prediction: Broncos win 21-17

Sunday, October 18th

Houston Texans vs. Jacksonville Jaguars, 9:30 AM ET (London)

We are going to count the London game this week as a primetime game. Jacksonville played in London in Week 5 and won a wild one against Philadelphia. The Jaguars are simply a better football team than the Houston Texans, and they'll be more acclimated to London as well.

The Jaguars don't have quite as much roster talent as the Texans do, but the Jags have the advantage at QB and with their coaching. Houston is 1-4 for a reason, and Jacksonville is 4-1 for a reason.

This should be a Jaguars victory, but in a game that also features two good defenses, we might not get a lot of scoring.

Prediction: Jaguars win 23-17

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